THE EFFICACY OF TAI-DING-AN ON THE INHIBITION OF HSV-I SKIN INFECTIONS IN GUINEA PIGS

Tai-DingyAn (TDA) is a derivative of thiosemicarbazone with anti-Chlamydozoa trachomatis activity and was used in clinic for treatment of trachoma in China. Tai-Ding-An was found to have anti-herpetic activities both in cell cultures and in guinea pig skin infections. Tai-Ding-An is insoluble in water but soluble in DMSO. 1～2% TDA in 60% DMSO applied topically on HSV-Ⅰ infected guinea pig skin, QID for 5 days. started 24 hrs after infection significantly inhibited the development of skin lesions. Since 2% TDA in 60% DMSO is a saturated solution, TDA precipitated on the skin and interfered with the healing of the lesions, so that it was less active than that of 1% TDA. 0.25% TDA in 25% DMSO and 2% TDA paste gave no significant therapeutic effect.