Advances in the study of HIV-1 integrase inhibitors of α, γ-diketo compounds

HIV-1 integrase (IN) is an essential enzyme for retroviral replication.  There is no analogue for this enzyme in human cells so that inhibition of IN will not bring strong effect on human body.  Thus, HIV-1 IN has become a rational target for therapy of AIDS.  This review provides a comprehensive report of α, γ-diketo IN inhibitors discovered in recent years.  Compilation of such data will prove to be beneficial in developing QSAR, pharmacophore hypothesis generation and validation, virtual screening and synthesis of compounds with higher activity.