STUDY ON VOLTAMMETRIC BEHAVIOUR OF CLOZAPINE AND ITS SINGLE-SWEEP OSCILLOPOLAROGRAPHY

A sensitive reduction peak of clozapine is obtained by singlesweep oscillopolarography in 0.1 mol·L^-1 H₂SO₄ solution. The peak potential is -0.95 V (vs.SCE). The peak current is directly proportional to the concentration of clozapine with a detection limit of 2.0×10^-8 mol·L^-1. The voltammetric behaviour of clozapine and its mechanism of electrode reaction have been studied by linearsweep and cyclic voltammetry and pulse polarography etc. The reduction process is irreversible with adsorptive characteristics. The number of electrons transferred n is 2. The electron transfer coefficient α is 0.62. Its behaviour obeys Langmuir adsorption isotherm. The adsorption coefficient β is 1.91×10⁶ L·mol^-1. The energy of adsorption ΔG⁰=-35.83 kJ·mol^-1. The method has been applied to the determination of clozepine in tablet and urine.