STUDIES ON CANCER CHEMOTHERAPY ⅩⅨ. SYNTHESIS OF N,N-BIS (β-CHLOROETHYL) HYDRAZONE DERIVATIVES

A series of N,N-bis (β-chloroethyl) hydrazones of testosterone, 17-methyl testosterone and other carbonyl compounds were synthesized for the investigation of their antitumour effect. The hydrazones were prepared by the condensation of N,N-bis (β-chloroethyl) hydrazine hydrochloride (Ⅰ) and appropriate carbonyl compound in ethanol with or without the addition of alkali. 17-p-Bis-(β-chloroethyl)aminobenzylidene-amino-△⁵-androstanol-3(Ⅵ) was also prepared from 17-amino-△⁵-androstenol-3 and p-bis (β-chloroethyl) amino benzaldehyde.