STUDIES ON THE CHEMICAL CONSTITUENTS OF KAEMPFERIA MARGINATA

AIM　To study the chemiacal constituents of the rhizomes of Kaempferia galanga L. (Zingiberaceae). METHODS　Various chromatographic techniques were used to separate and purify. Their physico-chemical properties and spectral data were used to elucidate the structures. RESULTS　Six compounds were isolated from the hexane extract of K.galanga. Their structures were identified as marginatol (1), 8(14),15-sanderacopimaradiene-1α,9α-diol (2), 8(14),15-sanderacopimaradiene-1α,6β,9α-triol (3), germacrone (4), trans-ethyl p-methoxycinnamate (5) and n-pentadecane (6) on the basis of spectral data (IR, MS, ¹H-¹H, ¹³C-¹H NMR, NOEs and HMBC). CONCLUSION　Marginatol (1) is a new isopimarene diterpenoid and was elucidated as 8(14),15-isopimaradiene-6α-ol. Compounds 2, 3 and 4 were isolated for the first time from this plant.