Synthesis and anti-active oxygen properties of water-soluble metal porphyrins

AimTo synthesize four water-soluble metal porphyrins ［5，10，15，20-tetra［4-(4′-pyridine-1) butyloxy phenyl］ metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)］ as analogous enzyme having two anti-active oxygen functions. MethodsThe first function, scavenging O^-₂, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H₂O₂, has been demonstrated by using the oxidating Vit C. The third function, scavenging HO^·, has been demonstrated by using Fenton reaction. The complexes were measured by the mice liver homogenate technique of mice. ResultsFour model compounds could scavenge O^-₂ in the concentration range of 1.0×10^-5-1.0×10^-6 mol·L^-1， decompose H₂O₂ in the concentration of 1.5×10^-6-1.0×10^-6mol·L^-1， scavenge HO^· in the concentration of 2.0×10^-8-1.0×10^-8 mol·L^-1. All showed that they had obvious action of decreasing the lipid peroxidation in the concentration of 1.0×10^-7 mol·L^-1. ConclusionAll above-mentioned complexes were considered to be qualified analogous enzymes of anti-active oxygen.