DISSOLUTION RATE AND BIOAVAILABILITY OF FAMOTIDINE TABLETS

An automated dissolution test system was used for the determination ofthe dissolution rate of famotidine tablets, and a mean cumulative dissolution rate of97.40±0. 31% in 15 rain was obtained. To each of six healthy volunteers, 40mg offamotidine tablets were administered orally, then an automated HPLC with switching co-lumm system was used to analyze famotidine in plasma. Variation of drug concentrationvs time were fitted to curves. By comparison of calculated values with observed ones, theresults could be described as one- compartment model in human. According to a statisticmoment algorithm, the results of calculation showed that T_1/2= 2.92 h and F_rel= 118.8%.