Pharmacokinetics of osthole in rabbits

AimTo investigate the pharmacokinetics of osthole in rabbits and obtain the main pharmacokinetic parameters. MethodsA simple high-performance 1iquid chromatography (HPLC) method was developed to study the pharmacokinetics of osthole in rabbits by joining an internal standard (paeonal). Methanol-water (80∶20) was used as the mobile phase. According to the 3P87 pharmacokinetic program, the main parameters were calculated. ResultsThe osthole pharmacokinetics conforms to a two compartment open model after iv administration, T_1/2α=5.81 min, T_1/2β=42.2 min, K21=0.036 0·min^-1,K₁₂=0.045 0·min^-1, K₁₀=0.054 0·min^-1, AUC=235 mg·min·L^-1, CLs=0.043 0 L·min^-1·kg^-1, V_C=0.780 L·kg^-1. ConclusionThe pharmacokinetics of osthole after iv administration showed a rapid distribution and elimination process in rabbits.