The function of protein kinase C in myocardial fibrosis

Myocardial fibrosis is the common results of the development of a variety of heart diseases  which leads to extracellular matrix protein metabolic disorders and causes cardiac remodeling owing to cardiac fibroblasts proliferation, eventually results in malignant arrhythmia, heart failure, and even the occurrence of sudden cardiac death.  Effective inhibition of myocardial remodeling could prevent the occurrence of sudden death.  To know the protein kinase C (PKC) effective mechanism of regulation on myocardial fibrosis, a new therapeutic target for reversing myocardial remodeling might be provided.