STUDIES ON ANTIMALARIAL AGENTS ⅩⅣ. SYNTHESIS OF TRIFLUOROMETHYL-QUINOLYL-TETRAHYDRONAPHTHOLS AND AMINOPHENOLS

Twelve 2-(alkylaminomethyl)- 4-(7′-trifluor omethyl-4′-quinolylamino) -5,6,7,8-tetrahydro-1-naphthols (Ⅰ) hydrochloride and thirteen 2-(alkylaminomethyl)-and 2,6- bis-(alkylaminomethyl)-4- (7′-trifluoromethyl-4′-quinolylamino) phenols (Ⅱ and Ⅲ) hydrochloride had been synthesized and screened for antimalarial activity against plasmodium berghei in mice. Preliminary results showed that all compounds exhibited marked antimalarial effect. Compound Ⅰ₃, Ⅲ₂ and Ⅲ₃ suppressed parasitemia at 2.5 mg/kg.