A IL-6R antagonist 2520A produced by a Fungal species

AimTo isolate IL-6R antagonists from the cultured broth of the strain Torulomyces ovatus. MethodsVarious column chromatographyes were used to separate and purify the compounds with IL-6R antagonist activity. The spectral data and physic-chemical properties were measured for structure identification. ResultsOne compound namely 2520 was isolated from the cultured broth of Torulomyces ovatus. Conclusion2520A is a known compound (ferrichrome). It is first reported about its antagonistic activity of IL-6R and identification of iron atom in its structure.