Synthesis of propenamides with anti-malarial activities and 3D-QSAR study

AimTo establish 3D QSAR model of propenamides with anti-malarial activities. Methods Chemical synthesis combined with comparative molecular field analysis (CoMFA). ResultsGenerated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6). ConclusionThe activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.