Wu Nan, Lu Yang, Zheng Qitai, Fang Weishuo, Gao Yongli, Fang Qicheng , Zhou Tonghui, . STUDIES ON THE FINE STEREOSTRUCTURE OF TAXOIDSJ. Acta Pharmaceutica Sinica, 1998, 33(10): 759-763.
Citation: Wu Nan, Lu Yang, Zheng Qitai, Fang Weishuo, Gao Yongli, Fang Qicheng , Zhou Tonghui, . STUDIES ON THE FINE STEREOSTRUCTURE OF TAXOIDSJ. Acta Pharmaceutica Sinica, 1998, 33(10): 759-763.
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STUDIES ON THE FINE STEREOSTRUCTURE OF TAXOIDS

    Abstract
  • The anticancer drug taxol is a new type antimicrotubular drug. The structure-activity relationship study on taxol and its analogs has indicated the importance of the C13 side chain and the C4-C5-C20 epoxypropane group. The crystal structures of 4 taxoids having the basic skeleton with 5/7/6 membered ring and three types of 10 taxoids having the basic skeleton with 6/8/6 membered ring have been analyzed. The effects of the induction by different substructures at C4 on the stereostructures of taxoids were studied, and the relationship between the 6/8/6/4 skeleton and the anticancer activity was discussed from the crystallographic point.
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