Han Guangdian, Qiang Zeyin, Zhu Liya, Wang Zhirong , Chen Jianmin, . SYNTHETIC STUDIES OF CONTRACETIVE DRUGS Ⅱ. THE SYNTHESIS OF 16α, 17α-DIHYDROXYPROGESTERONE ACETOPHENIDEJ. Acta Pharmaceutica Sinica, 1980, 15(12): 725-729.
Citation: Han Guangdian, Qiang Zeyin, Zhu Liya, Wang Zhirong , Chen Jianmin, . SYNTHETIC STUDIES OF CONTRACETIVE DRUGS Ⅱ. THE SYNTHESIS OF 16α, 17α-DIHYDROXYPROGESTERONE ACETOPHENIDEJ. Acta Pharmaceutica Sinica, 1980, 15(12): 725-729.
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SYNTHETIC STUDIES OF CONTRACETIVE DRUGS Ⅱ. THE SYNTHESIS OF 16α, 17α-DIHYDROXYPROGESTERONE ACETOPHENIDE

    Abstract
  • The synthesis of 16α, 17α-dihydroxyprogesterone acetophenide (1) is reported. Starting from pregna-5,16-dien-3-ol-20-on, 3-acetate(Ⅳ), via potassium permanganate oxidation, condensation with acetophenone in presence of acid, followed by alkaline hydrolysis and Oppenauer oxdation, the object compound (1) was obtained. The △6-(Ⅵ) and △3,5-3-deoxy-(Ⅹ) derivative were also synthesized.
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