XS Jia, YL Wang, FS He, YF Shan, YF Li , Y Wang, . SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1993, 28(6): 477-480.
Citation: XS Jia, YL Wang, FS He, YF Shan, YF Li , Y Wang, . SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDSJ. Acta Pharmaceutica Sinica, 1993, 28(6): 477-480.
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SYNTHESIS AND ANTIBACTERIAL ACTION OF 1-ETHYL-6-FLUORO-1, 4-DIHYDRO- 4-OXO-7-(4-AROYLTHIOCARBAMOYL-1 -PIPERAZINYL)- 3-QUINOLINE CARBOXYLIC ACIDS

    Abstract
  • Thirteen new 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-aroyl-thiocarbamoyl- 1 piperazinyl)-3-quinoline carboxylic acids were prepared, Their structures were characterized by elemental analysis, IR, HNMR and MS spectra.Preliminary pharmacological tests indicated that some of compounds Ia～m possess strong inhibiting activity against Escherichia coli, Bacillus subtilis and Proteus at concentration of 100 μg/ml.
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