APPLICATION OF SECOND DERIVATIVE SPECTROMETRY TO THE DETERMINATION OF BROMHEXINE HYDROCHLORIDE AND SPECTROPHOTOMETRY TO THE DETERMINATION OF DYPHYLLINE IN COMPOUND PREPARATION

Bromhexine hydrochloride in compound preparations was determined directly by using second derivative spectrometry. Dyphylline was determined by using spectrometry. The proposed method is simple and rapid without any preliminary separation. The results obtained are satisfactory both in recovery and in precision. The average recoveries of bromhexine HCl and dyphylline were 99.59±0.72%(CV), and 100.6 ± 0.47% (CV), respectively.