EFFECTS OF EIGHT ANTIEPILEPTIC DRUGS ON CODIARIAE AND ELECTRIC INDUCED CONVULSION AND IMPAIRMENT OF LEARNING AND MEMORY IN MICE

For evaluation of the effect of eight antiepileptic drugs on epileptic seizures, both electric and coriariae-induced epileptic models in mice were used. Effect sof these drugs on learning and memory was also observed using passive avoidance learning-step down and step through tests in mice. Results showed that clonazepam and nitrazepam exhibited the most effective in antagonizing coriariae-induced epileptic seizures, then was pentobarbital and valproate in decreasing order. On the contrary, carbamezepine and Ag-1 deteriorated the coriariae-induced convulsion, While in the electric convulsion model, the effective order was phenytoin, phenobarbital, carbamezepine and valproate. Ag-1, antiepilepsirine, nitrazepam and clonazepam were inactive. All drugs but Ag-1 impaired acquisition of memory in normal mice. Nitrazepam and clonazepam improved impairment of consolidation of memory induced by coriariae. Nitrazepam and phenytoin destroyed the deficit of memory induced by electric convulsion. Other antiepilcptic drugs showed no effect on memory in both epileptic models.