SYNTHESIS AND BACTERIOSTATIC ACTIVITY OF 2-FURANTHIOCARBOXYHYDRAZONES AND THEIR TRANSITION METAL COMPLEXES

In this paper, 9 compounds of 2-furanthiocarboxyhydrazones and 13 of their transition metal complexes have been synthesized and tested for bacteriostatic activity against several kinds of bacteria. The results showed that all the compounds tested possessed antibacterial activity. The complexes of Cu(Ⅱ), Ni(Ⅱ) and Zn(Ⅱ) ions display higher activity against gram-positive bacteria than 2-furanthiocarboxyhydrazones and the other complexes. The complex of Ag(Ⅰ) ion is more active aganst gram-negative bacteria, as compared to 2-furanthiocarboxyhydrazones and the other comlexes. The results are also in accord with the earler idea that the "NCS" group is the active site and that their activity has certain relation with their complexing ability.