ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
Citation:
ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
Citation:
ZC Miao, ZH Du, GF Xu , TS Shi, . A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMRJ. Acta Pharmaceutica Sinica, 1988, 23(9): 682-687.
A STRUCTURAL STUDY OF THE INCLUSION COMPOUND OF PIROXCAM WITH β-CYCLODEXTRIN BY NMR
A structural study of the inclusion compound of piroxcam with β-cyclodextrin in aqueous solution was attempted by 1H-NMR, DQF-COSY and 2DNOE. The results of chemical shift changes and NOE suggests that when the molar ratio of piroxcam to β-cyclodextrin is one, the phenyl ring of piroxcam is predominantly included within the β-cyclodextrin cavity, forming a 1:1 inclusion compound.
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