DERIVATIVES OF ARTEANNUIN B WITH ANTILEUKEMIA ACTIVITY

DA Deng, CH Xu, JC Cai. DERIVATIVES OF ARTEANNUIN B WITH ANTILEUKEMIA ACTIVITYJ. Acta Pharmaceutica Sinica, 1992, 27(4): 317-320.

Citation:

DA Deng, CH Xu, JC Cai. DERIVATIVES OF ARTEANNUIN B WITH ANTILEUKEMIA ACTIVITYJ. Acta Pharmaceutica Sinica, 1992, 27(4): 317-320.

Citation:

DA Deng, CH Xu, JC Cai. DERIVATIVES OF ARTEANNUIN B WITH ANTILEUKEMIA ACTIVITYJ. Acta Pharmaceutica Sinica, 1992, 27(4): 317-320.

Abstract

Arteannuin B (I) was converted to hydroxy lactones (Ⅶ, Ⅷ) by amixture of formic acid and sulfuric acid. Compound Ⅵ and Compound Ⅶ both showedactivity against leukemia P 388 cell in vitro. The rate of growth inhibition were 97.5%and 11.8% for(Ⅵ)and 80% and 52.6% for(Ⅶ)at the concentration of 10 and 1μg/mlrespectively. It seems that the antileukemia activity of 6- membered lactone is higher thanthat of 5- membered and the methylene group is necessary for the antileukemia activity.

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