PH Li, YH Pang. DNA-BREAKING ACTION OF ASCORBIC ACID IN THE PRESENCE OF Cu (Ⅱ)/DEMETHYLCANTHARIC ACID COMPLEXJ. Acta Pharmaceutica Sinica, 1991, 26(11): 871-875.
Citation: PH Li, YH Pang. DNA-BREAKING ACTION OF ASCORBIC ACID IN THE PRESENCE OF Cu (Ⅱ)/DEMETHYLCANTHARIC ACID COMPLEXJ. Acta Pharmaceutica Sinica, 1991, 26(11): 871-875.
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DNA-BREAKING ACTION OF ASCORBIC ACID IN THE PRESENCE OF Cu (Ⅱ)/DEMETHYLCANTHARIC ACID COMPLEX

    Abstract
  • Effects of various factors on the DNA- breaking action of ascorbic acid in the presence of Cu(Ⅱ)/demethylcantharic acid complex were studied in phosphate buffer (pH 7.40 ), at 37.0±0.1℃.It was shown that·OH produced from Fenton reaction of H2O2 which can be formed from the oxidation of ascorbic acid was responsible for the DNA- breaking action of ascorbic acid and the simple Fenton reaction cannot explain all the results.
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