Synthesis of Derivatives of 5,6-Disubstituted 3(β-Aminoethyl) lndole

Nineteen derivatives of 3-indolylethyl amine were synthesized by treating substituted indoles with oxalyl chloride to form 3-indolyl glyoxylyl chloride, which on treatment with the requisite amines and subsequent reduction of the corresponding amides obtained with lithium aluminium hydride gave the required products. Pharmacological tests showed that the compound (Ⅱ)₇ possesses tranquilizing, anticonvulsant, and analgesic properties. Detailed pharmacological results will be reported elsewhere.