DETERMINATION OF THE OPTICAL PURITY OF PRAZIQUANAMINE BY REVERSED PHASE HPLC AFTER DERIVATIZATION WITH GITC

The enantiomers of praziquanamine were separated by reversed phase HPLC after derivatization with 2,3,4,6- tetra- O- acetyl- β-D- glucopyranosylisothiocyanate (GITC). The determination of the optical purity of praziquanamine was successfully achieved. This method was applied to the determination of the optical purity of d-and l-praziquanamines.