Study on semi-synthetic transforming technology for the natural product of isocorydione

Transforming technology for semi-synthesized isocorydione from the natural product of isocorydine was studied.  The factors affecting on the reaction yield were investigated.  UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione.  The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 ℃ and the ratio of isocorydine to Fremy’s radical was 1∶2.  Under the optimum conditions, the yield could reach up to 50.0%.  The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.