LI An-long, LIU Zhong-wu, ZHU Li-xia, ZHANG De-chang, YE Yi-xin. Activation of Ca2+-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cellsJ. Acta Pharmaceutica Sinica, 2004, 39(2): 101-104.
Citation: LI An-long, LIU Zhong-wu, ZHU Li-xia, ZHANG De-chang, YE Yi-xin. Activation of Ca2+-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cellsJ. Acta Pharmaceutica Sinica, 2004, 39(2): 101-104.
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Activation of Ca2+-activated K+ channels by oxyphenamone in rabbit mesenteric vascular smooth muscle cells

    Abstract
  • AimTo study the effects of oxyphenamone (Oxy) on activation of Ca2+-activated K+ channels in rabbit mesenteric vascular smooth muscle cells. MethodsTo measure the effect of Oxy on the Ca2+-activated K+ channel (BK (Ca) channel) activity in rabbit mesenteric vascular smooth muscle cells by using whole cell patch clamp techniques. ResultsOxy reversibly increase BK (Ca) channel activity in rabbit mesenteric artery smooth muscle cells. Application of Oxy (0.1 μmol·L-1) to the perfusion solution caused significant increase in outward currents and its effect was completely abolished by washout; The outward currents K+ was inhibited by TEA (7.5 mmol·L-1); Oxy activated the BK (Ca) channel in a dose-dependent manner (0.01-10 μmol·L-1). ConclusionOxy directly increase the activity of BK (Ca) channel activity in rabbit mesenteric vascular smooth muscle cells in dose-dependent manner.
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