Yan Ligang, Xu Bingxiang, Ma Zhenyeng, Zhu Yanjing , Yang Qinghua, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDJ. Acta Pharmaceutica Sinica, 1998, 33(5): 392-395.
Citation: Yan Ligang, Xu Bingxiang, Ma Zhenyeng, Zhu Yanjing , Yang Qinghua, . SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDJ. Acta Pharmaceutica Sinica, 1998, 33(5): 392-395.
shu

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF 7-SUBSTITUTED-1-ETHYL(2-FLUORO-ETHYL)-6,8-DIFLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID

    Abstract
  • Eighteen 7-substituted-1-ethyl(2-fluoroethyl)-6,8-difluoro-1,4-dihydro-4-oxoquinolone-3-carboxylic acid were designed and synthesized. The results of preliminary antibacterial test showed that most of the compounds exhibited definite activities in test against pathogenic bacteria. Especially, compound 17 and 18 showed better activities and surpassed fleroxacin when compared in vitro.
    • FullText(HTML)
  • loading
    • References (0)
    • Relative Articles
  • Supplements (0)

Catalog

    Turn off MathJax
    Article Contents

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return