SYNTHESIS OF GANODERMA ALKALOID A AND B

Ganoderma alkaloid A (Ⅰ_a, 1-isopentyl-2-formyl-5-hydroxy-methylpyrrole) and B (Ⅰ_b, 1-phenylethy 1-2-formyl-5-hydroxymethylpyrrole) were discovered in the hypha of deep fermented Ganoderma capense. Both are new pyrrole alkaloids. In order to provide samples for bioassay, we completed the synthesis of these new alkaloids and their acetyl derivatives. The route of synthesis included six steps. Thewhole yields were 20.7% for Ⅰ_A and 24.7% for Ⅰ_B. Synthetic Ⅰ_A and Ⅰ_B were found to be identical with the natural compounds by comparison of spectral data.Ⅰ_A and Ⅰ_b showed some antiinflammatory activity in animal experiments.