YX Xu, L Shen , CJ Zhang, . ANALYSIS OF DEXTROMETHORPHAN AND ITS METABOLITES IN HUMAN URINE BY USING GAS CHROMATOGRAPHY-MASS SPECTROMETRYJ. Acta Pharmaceutica Sinica, 1993, 28(2): 156-159.
Citation: YX Xu, L Shen , CJ Zhang, . ANALYSIS OF DEXTROMETHORPHAN AND ITS METABOLITES IN HUMAN URINE BY USING GAS CHROMATOGRAPHY-MASS SPECTROMETRYJ. Acta Pharmaceutica Sinica, 1993, 28(2): 156-159.
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ANALYSIS OF DEXTROMETHORPHAN AND ITS METABOLITES IN HUMAN URINE BY USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY

    Abstract
  • A GC-MS method for the analysis of dextromethorphan and its metabolites is described. The urine sample was hydrolyzed with HCl, extracted with diethyl ether and derivatized with MSTFA (N-methyl-N-trimethylsilyltrifluoroacetamide)-MBTFA (N-methyl-bistrifluoroacetamide). Dextromethorphan and its 3 metabolites were detected in urine samples within 2～60 h after administration of the drug. Their structures and the variation of their concentration in urine were determined. The detection limit of dextromethorphan is 10 ng.
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