METHOD OF OPTIMIZATION OF THE SOLVENT SYSTEM FOR THIN LAYER CHROMATOGRAPHY

In this article, we analized 81 usual solvents with Fuzzy group analytical method by a computer at first, and selected 20 better solvents for TLC. Then optimized the solvent system for TLC by means of uniform design test and optimization method——simplex method. We also worked out a modified chromatographic optimization function. This systematized method has been shown to be effective and practical in our experiments. It is not only fit to TLC, but also fit to paper chromatography and liquid chromatography. So far, no similar report has been found in the literature.