EXPONENTIAL PROGRAMMED FOR DRUG STABILITY EXPERIMENT

A new programmed heating model(exponential heating model)for drug stabilityexperiment is intreduced.In this heating model,the temperature rising rate dT/dt is increased 2～4 times when the temperature increases by every 10℃ to fit most chemical reactions:dT/dt=a^(T-T₀)/10·(dT/dt)₀.A comparison of the new heating model and the linear,reciprocal,andlogarithmic heating models is made and discussed.The results indicate that in the new programmedheating experiment,the degradation of drugs can be more uniform within different temperature rangesand the experimental results can be more accurate than those in the linear,reciprocal,or logarithmicheating experiment.A computation method with optimization and numerical integration for the newprogrammed heating experiment is also introduced.In this computation method, there is no need forapproximation.