SF Yin, W Zhuang, WY Ma, ZG Wang, TD Wang, XH Chen , CN Zhang, . SYNTHESIS AND ANTITUMOR ACTIVITY OF 4-S-(5-AMIDO-1,3,4-THIODIAZOL-2-YL)4-DEOXY-4′-DEMETHYLEPIPODOPHYLLOTOXIN ANALOGUESJ. Acta Pharmaceutica Sinica, 1993, 28(10): 762-765.
Citation: SF Yin, W Zhuang, WY Ma, ZG Wang, TD Wang, XH Chen , CN Zhang, . SYNTHESIS AND ANTITUMOR ACTIVITY OF 4-S-(5-AMIDO-1,3,4-THIODIAZOL-2-YL)4-DEOXY-4′-DEMETHYLEPIPODOPHYLLOTOXIN ANALOGUESJ. Acta Pharmaceutica Sinica, 1993, 28(10): 762-765.
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SYNTHESIS AND ANTITUMOR ACTIVITY OF 4-S-(5-AMIDO-1,3,4-THIODIAZOL-2-YL)4-DEOXY-4′-DEMETHYLEPIPODOPHYLLOTOXIN ANALOGUES

    Abstract
  • By the condensation of 4'-demethylepipodophyllotoxin with 2-amino-5-mereapto-1,3, 4-thiodiazole in CF3COOH and acylation in the presence of DEPC, 10 title compounds wereconveniently synthesized. These compounds were screened in vitro against L1210 leukemia and KB cells,in which compounds SIPI-92-1772, 1774, 1775, 1776, 1777 and 1779 exhibited more potent antitumor activity.
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