SYNTHESIS OF SOME DERIVATIVES OF 2-METHYL-3-(γ-AMINOPROPYL)-5, 6-METHYLENEDIOXYINDOLE

In continuation of our study on indole derivatives, eight substituted 3-(γ-aminopropyl)-indoles were prepared. 2-Methyl-5,6-methylenedioxyindole reacted with acrylic acid in the presence of acetic anhydride to give 2-metbyl-5,6-methylenedioxyindolepro-pionic acid, which on treatment with SiCl₄ followed by reaction with requisite amines gave the corresponding amides. The amides thus obtained were readily reduced to the expected products with LiAlH₄.An attempt to obtain the title compounds by treating substituted indole with malonyl chloride followed by amination and reduction was unsuccessful.Preliminary pharmacological tests revealed that compound Ⅳ showed marked effect on potentiation of hexobarbital hypnosis with relatively low toxicity.