SYNTHESIS OF 4-, 6- OR 7- SUBSTITUTED PHENYLIMINOMETHYLENECOUMARINS AND THEIR ANTICANCER ACTIVITIES

AIMA series of substituted phenyliminomethylenecoumarins derivatives was designed in order to find compounds possessing anticancer activities. METHODSTitle compounds (1a～b, 2a～b and 3a～q) were synthesized and screened by several anticancer models in vitro. RESULTSTwenty-one new compounds (1a～b, 2a～b and 3a～q) were synthesized and screened. Structrues of the new compunds were determined by MS, HNMR and elemental analysis. Twelve compounds (3c, 3d, 3e, 3f, 3g, 3h, 3j, 3k, 3m, 3o, 3p, 3q) showed inhibitory effects on HCT-8, KB and Bel7402 cell lines in vitro. CONCLUSIONSome compounds had certain anticancer activities and were worth further studying.