SYNTHESIS AND BIOLOGICAL ACTIVITY OF 1-(4-ALKYLOXY)BENZYL-1,2,3,4-TETRAHYDROISOQUINOLINES AND RELATED COMPOUNDS

In an attempt to search for novel cardiovascular drugs which might act on calcium or potassium channels, on the basis of the previous study of our group,15 1-(4-alkyloxy)benzyl-1,2,3,4-tetrahydroisoquinolines derivatives were designed and synthesized among which 10 were not reported previously in the literature.Preliminary pharmacological studies showed that most of these compounds exhibited relaxation of rat thoria aorta in vitro. Compound III₉ exhibited potent inhibiting action on low KCl(20 mmol·L^-1)-induced contraction of rat aorta, and significant protective effect on experimental arrhythmia in rats.