STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDES

RT Li; HC Chen , JZ Yang

RT Li, HC Chen , JZ Yang, . STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 144-149.

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RT Li, HC Chen , JZ Yang, . STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 144-149.

Citation:

RT Li, HC Chen , JZ Yang, . STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDESJ. Acta Pharmaceutica Sinica, 1995, 30(2): 144-149.

STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDES

RT Li,
HC Chen , JZ Yang,

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Abstract

In order to search for potential antitumor drugs of piperazincs,1-(3-chloro-2- hydroxypropyl)-4,4-dialkylpiperazine bromides(Va～g)were prepared.In preliminary toxicity and antitumor activity tests compounds Vb～d showed low toxicity,compounds Vb and Vc exhibited some inhibitory activity against carcinoma S₃₇ in rats.

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STUDIES ON ANTITUMOR DKUGS OF PIPERAZINES:SYNTHESIS OF 1-(3-CHLORO-2-HYDROXYPROPYL)- 4,4-DIALKYLPIPEKAZINE BROMIDES

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