ANTAGONISM OF DAURISOLINE ON ARRHYTHMOGENIC DELAYED AFTERDEPOLARIZATION

Standard microelectrode technique was used to study the effect of daurisoline(DS)on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 umol·L^-1)abolished TA induced by ouabain or caffeine．inhibited isoprenaline-induced TA，decreased incidence of TA induced by K⁺-free and high-Ca²⁺ medium or phenylephrine from 100，75％ to 9.1％and 22.2％ respectively，and significantly suppressed DAD caused by the above induces. It is concluded that DS exert antagonistic action to DAD and TA in guinea pig trabeculae．