STUDIES ON THE CONSTITUENTS OF PATRINIA VILLOSA

Patrinia villosa is a useful and common medicine in China. However, the constituents of this plant have not been reported. Two new Iridoid laetones named villosol (Ⅳ) and villosolside (Ⅴ) were isolated from the alcohol soluble part of the dried herb, besides known compounds oleanolic acid and palmitic acid. Their structure and stereochemistry were established on the basis of analysis of spectral data, preparation of derivatives and chemical transformation. It is interesting that these two new iridoids have uncommon skeleton and a β-Dglucose attaches to the Ca to form a glucoside especial unusually.