Recent progress in the study of HIV-1 transcription factor NF-κB and its inhibitors

Human immunodeficiency virus type 1 (HIV-1) transcription is a crucial step in the viral replication cycle, which is considered to be a potential target for inhibition of HIV-1 replication. Among the factors involved in this step, the cellular protein nuclear factor NF-κB is the most powerful inducer of HIV-1 transcription. HIV-1 transcription is initiated by the binding of NF-κB to the enhancer region in the long terminal repeat (LTR) of HIV-1. Several compounds suppress HIV-1 transcription through the inhibition of NF-κB activation. The mechanisms of NF-κB in the transcription of HIV-1 and progress of the current inhibitors of NF-κB are reviewed.