STUDIES ON THE STRUCTURE OF A NEW ANTITUMOR AGENT-HAINANOLIDE

Two new constituents, hainanolide and hainanolidol, were isolated from the bark of Cephalotaxus hainanensis Li. Hainanolide, whose structure as shown in this paper elucidated on the basis of X-ray crystallography and Spectrometric data(IR, UV, NMR, MS), was found to be active against sarcoma 180, Walker carcinosarcoma 256, Lewis lung carcinoma, L615 leukemia, P388 leukemia and L1210 leukemia. The structure of hainanolidol is still under investigation.identical with harringtonolide.