EFFECT OF ACETYLSALVIANOLIC ACID A ON PLATELET FUNCTION

Acetylsalvianolic acid A(ASAA) is an semisynthetic analogue of salvianolic acidA, isolated from Danshen(Salvia miltiorrhiza Bunge).In in vitro experiments,ASAA showed markedinhlbitory effect on rat and rabbit platelet aggregation induced by ADP, collagen,arachidonic acid(AA) and thrombin. In ex vivo experiments with ADP,collagen,and AA as inducers, ASAA was alsoshown to inhibit platelet aggregation remarkably. The effect lasted more than two hours. In addition,ASAA was found to have suppressive effect on collagen induced platelet 5-HT release while inhibitingaggregation. The above results seemed to suggest that ASAA may be a widely effective inhibitor ofplatelet function.