EFFECTS OF TETRANDRINE ON CARDIAC HEMODYNAMICS OF HYPERTROPHIED LEFT VENTRICLE FROM DEOXYCORTICOSTERONE-SALT HYPERTENSIVE RATS

Effects of tetrandrine(Tet)on cardiac mass and hemodynamic parameters were studied in deoxycorticosterone-salt(DOCA-salt )hypertensive rats. Treatment with Tet(50mg·kg^-1,qd X 9 wk)markedly lowered systolic blood pressure and left ventricular(LV) weight,Study on isolated working heart demonstrated that the Tet group compared with the LVH group, AP,LVSP,±dp/dt_max, LVDP,coronary blood flow and cardiac output were increased while LVEDP andT were decreased. Studies on LV pressure-volume relation showed that Tet can markedly improve theLV compliance and the LV stiffness constant of LVH ra. These findings suggest that the regression ofLVH in DOCA-salt hypertensive rats with Tet is associated with improvement of the contraction,relaxation and pump function , especially relaxation function and hemodynamics.