A new coumarin glycoside from Glehnia littoralis

To study the chemical constituents from Glehnia littoralis, macroreticular resin column chromatography, repeated column chromatography on Sephadex LH-20 and reverse phase ODS were used to isolate the compounds whose structures were elucidated based on spectroscopic data (ESI-MS, 1D and 2D NMR). A new coumarin glycoside was isolated and identified as： bergaptol 5-O-β-D-gentiobioside (1), along with eight known compounds: (7R,8S)-dehydrodiconiferylalcohol-4,9-di-O-β-D-glucoside (2), cirtrusin A (3), (-)-seco-isolariciresinol 4-O-β-D-glucopyranoside (4), baihuaqianhuside (5), xanthotoxol 8-O-β-D-glucopyranoside (6), 5′-methylthioadenosine (7), adenosine (8), L-tryptophan (9). Compound 1 is a new coumarin glycoside,compounds 2 and 7 were isolated from this genus for the first time.