STUDY ON PORPHYRINS:SYNTHESIS AND ANTITUMOR ACTIVITY OF PORPHYRIN-FLUOROURACIL COMPOUNDS

Three covalently linked porphyrin- fluorouracil compounds were synthesized. Measurement using these compounds for inhibition of mice transplanted tumor growth, cytotoxicity to mice cancer cells and the mice ear index under exposure to a light was performed. The results indicated that all these compounds were phototoxic to the cancer cells, and compound 1 was the most effective among them.