STUDIES ON ANTIFUNGAL AGENTS VI. SYNTHESIS AND ANTICANDIDAALBICANS ACTIVITY OF CTERMINAL CONTAINING MEDP PEPTIDES

AIM: To search for compounds having strong antifungal activities. METHODS AND RESULTS: Twelve new peptides containing MEDP(N³-(2-R,3R)-4-methoxyepoxysuccinyl-L-2,3-diaminopropanoic acid) in Cterminus have been synthesized and evaluated in vitro against Candida albicans on the basis of “illicit transport”. CONCLUSION: Some of them have strong activities. The MMIC(molar mininum inhibitory concentrations) of ValMEDP, the most active peptide in this series, is 448 nmol·mL^-1, 960 times the MMIC of MEDP. But all of the peptides showed weaker activities than the related peptides containing FMDP(N³-4-methoxyfumaryl-L-2,3-diaminopropanoic acid).