Synthesis and antithrombotic activity of acetylsalicyl ferulic acid-coupling furoxans and nitrates

AimTo synthesize and study the antithrombotic activity of NO-donating aspirin derivatives. MethodsFuroxans and nitrates were incorporated to aspirin via antioxidant ferulic acid as a linker, and the target compounds were screened for in vitro and in vivo inhibitory activities of platelet aggregation, and for inhibitory effect on A-V bypass thrombosis in rats. ResultsFourteen novel compounds I_1-14 were synthesized and their structures were confirmed by MS, IR, ¹H NMR and elemental analysis. Biological screening results demonstrated that some tested compounds exhibited potential antithrombotic activity. ConclusionAcetylsalicyl ferulic acid -coupling furoxans and nitrates might be used as a lead for further study.