SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NOVEL 6-FLUOROQUINOLONE ANALOGUES

A series of,8- disubstituted 1-eyclopropy1 and 1-ethy1-6-fluoro-1,4- dihvdro-4- oxo-3- quinolinecarboxylic acid derivatives have been synthesized and evaluated for antihacterial activity in vitro, Among these compounds,7-(4-Acetoxypiperidinyl)-8- chloro-l-cyclopropy1-6-fluoro-1,4- dihydro-4-oxo- 3- quinolinecarboxylic acid(llc)and 8-chloro-l- cyclopropy1- 6- fluoro-7-(4- hydroxypiperidiny1)-1,4-dihydro-4- oxo-3-quinoline- carboxylic acid(llb)showed higher potency in vitro, particularly against Staphylococcus aureus,Methicllin-resistant staphylococcus aureus(MRSA)and Pseudomonas aeruginosacompared with ciprofloxacin.