Recent advances in the study of bioreductive drugs targeted tumor hypoxia

Tumor hypoxia is the necessary process in the development of solid tumors, which is the key  factor for drug resistance, recurrence, attack and shift of tumor.  Hypoxic tumor cells have a certain extent of tolerance to radiation and chemotherapy.  Tumor hypoxia is an important target for medication therapy.  In the recent years, the bioreductive drugs targeted tumor hypoxia has made great process in the treatment of tumors.  The latest advances of bioreductive drugs targeted hypoxia were reviewed in this paper.