THE ANTI-INFLAMMATORY ACTIONS OF BENZOISOSELENOTHIAZOLIDONESULFONAMIDE DERIVATIVES

AIM　To study the anti-inflammatory effects of benzoisoselenothiazolidonesulfonamide derivatives, compounds A and B. METHODS　Boyden chamber was used to examine the chemotaxis of polymorphonuclear leukocyte. Myeloperoxidase activity was assayed by spectrophotometry. Dying method was used to study degranulation of mastocytes. RESULTS　Compounds A and B were shown to inhibit the chemotaxis of polymorphonuclear leukocyte stimulated by fMLPP with IC₅₀ of 1.3×10^-8　mol.L^-1 and 1.19×10^-10　mol.L^-1,　respectively. In the model of mouse ear edema induced by croton oil, the rates of inhibition of myeloperoxidase activity after compounds A and B applied to the dorsal surface of mouse ear were 49% for compound A at the dose of 1　mg/mouse, 37% and 51% for compound B at the doses of 0.1　mg/mouse and 1　mg/mouse, respectively. Compounds A and B（10^-7～10^-5　mol.L^-1）　showed dose-dependent inhibitory activity relationship with respect to the degranulation of mastocytes response to compound　48/80. CONCLUSION　Benzoisoselenothiazolidonesulfonamide derivatives compound A and compound B showed obvious anti-inflammatory effects.