EFFECT OF CAMPHORAMINE CHLOROACETIC PLATINUM (CCP) ONBIOMACROMOLECULES IN L₁₂₁₀ LEUKEMIC CELL

Camphoramine Chloroacetic Platinum (CCP) is a new anticancer platinum complex. In the present paper, the effects of CCP on contents and biosynthesi of DNA, RNA and proteins of L₁₂₁₀ leukemic cell in DBA/2 mice and the mode of action of CCP on DNA template by using isotope and fluoresent probe techniques are reported. Preliminary results revealed that CCP decrease the contents of DNA, RNA and proteins of L₁₂₁₀ leukemic cell in vivo and in vitro and has remarkable inhibition on biosynthesis of DNA in L₁₂₁₀ cell. The action of CCP may be to damage the DNA template and bind to DNA covalently and noncovalently.