SYNTHESIS AND CARDIOVASCULAR ACTIVITIES OF PEPTIDYL DOPAMINE DERIVATIVES

Amino acids and small peptides with different steric configurat ions and lipophilicities were aprended to dopamine. Eighteen compounds have been synthesized. The attachment of D-amino acids or N-methyl amino acids onto the dopamine molecule caused a marked decrease in cardiovascular activity by intravenous injection, while the introduction of lipophilic amino acids caused a marked increase in myocardial contractility and blood pressure in anesthetized dogs. The durations of action were also prolonged.